NCT07373730

Evaluation of the Efficacy of Injectable Platelet-Rich Fibrin Mixed With Hyaluronic Acid in Treatment of Temporomandibular Joint Internal Derangement

Clinical and Radiographic Evaluation of the Efficacy of Injectable Platelet Rich Fibrin Mixed With Hyaluronic Acid in Treatment of Temporomandibular Joint Internal Derangement: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Suez Canal University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

we inject I-PRF and Hyaluronic Acid inside the human TMJ with internal derangement after arthrocentesis, and follow-up is made to evaluate the effect of this treatment.

Detailed description

This study was made to evaluate the efficacy of injectable Platelet Rich Fibrin (I-PRF) with Hyaluronic Acid (HA) injection after arthrocentesis in treatment of Temporomandibular joint Internal Derangement. The study was conducted on 30 patients whose ages ranged from 18 to 40 years, presented with impaired jaw function, limited mouth opening, Pain during joint movement and clicking. TMJ internal derangement was verified by preoperative MRI. Patients with MPDS only, systemic debilitating disease, previous surgery in the TMJ, previous arthrocentesis, previous trauma to the joint were excluded from the study. Control group: 15 cases were treated by arthrocentesis then injection of 1ml of Hyaluronic acid (HA). Study group: 15 cases were treated by arthrocentesis then injection of 0.5ml of Hyaluronic acid (HA) and 0.5ml of injectable platelet rich fibrin (I-PRF). Clinical assessment of pain by VAS, clicking as present or not, maximum mouth opening in millimeters, right and left lateral movements and protrusive movements was done preoperatively and postoperatively at 1,3,6 months. MRI assessment was done preoperatively and 6 months postoperatively.

Conditions

• Temporomandibular Joint Disc Displacement

Interventions

Type	Name	Description
DRUG	Hyalgan 20 mg in 2 ML Prefilled Syringe	For the control group: 1mm of the drug was injected into the joint. For the study group: 0.5mm of the drug was injected into the joint.
OTHER	I-PRF	Only given for the study group: 0.5mm of I-PRF was injected into the joint.

Timeline

• Start date: 2023-08-10
• Primary completion: 2024-06-20
• Completion: 2025-07-31
• First posted: 2026-01-28
• Last updated: 2026-01-28

Locations

1 site across 1 country: Egypt