NCT07373210

Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy

Conditioning, Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy (PAO)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 13 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

In this randomized controlled trial, 64 participants undergoing PAO at UCSF will be enrolled and randomized to receive either COLP plus treatment as usual (TAU) or TAU alone. Patients in the COLP arm will receive placebo pills alongside prescribed opioids and at scheduled intervals, beginning on postoperative day one. Weekly follow-up will be conducted for six weeks postoperatively via remote surveys and video visits.

Conditions

• Periacetabular Osteotomy
• Opiates

Interventions

Type	Name	Description
OTHER	Open-Label Placebo	One placebo tablet will be taken with each oral opioid dose, 5mg Oxycodone, 6 times per day, beginning on post-operative day 1.
OTHER	Treatment as usual	Treatment As Usual (TAU) participants will receive their standard opioid dose, 5mg Oxycodone pill, 6 times a day beginning on post-operative day 1.

Timeline

• Start date: 2026-03-01
• Primary completion: 2028-03-31
• Completion: 2028-03-31
• First posted: 2026-01-28
• Last updated: 2026-03-13

Locations

1 site across 1 country: United States