NCT07370779

The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital · Other Government
• Sex: All
• Age: 6 Months – 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position. The findings indicated that the application of PEEP did not result in a significant difference in ONSD. Although a significant decrease in systolic and diastolic blood pressure was observed with the use of PEEP, these values remained within normal ranges and did not indicate adverse hemodynamic effects. The results suggest that the use of a PEEP level of 4 cmH2O in pediatric patients with intracranial masses is safe and may be applied during the perioperative period.

Conditions

• Craniotomy Surgery
• Pediatric Patient Safety
• Pediatric Patient
• Positive End-expiratory Pressure (PEEP)
• Optic Nerve Sheath Diameter Measurement

Interventions

Type	Name	Description
DRUG	General Anesthesia	General anesthesia was administered according to standard clinical practice, including intravenous induction agents and inhalational anesthetics, as part of routine perioperative care.
DRUG	Anesthetic Agents	Anesthetic agents, including propofol, fentanyl, rocuronium, and sevoflurane, were used as part of standard anesthetic management during the procedure.
DEVICE	mechanical ventilation (MV)	Mechanical ventilation was provided using a standard anesthesia ventilator in volume-controlled mode during surgery.

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-10-30
• Completion: 2021-10-30
• First posted: 2026-01-27
• Last updated: 2026-01-27

Locations

1 site across 1 country: Turkey (Türkiye)