NCT07369570

Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging

A Prospective Study of the Evolution of Lesions in Repeated Biparametric Prostate Magnetic Resonance Imaging

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of Eastern Finland · Academic / Other
• Sex: Male
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to prospectively investigate the evolution of lesions in biparametric magnetic resonance imaging (bpMRI) of the prostate in men with no clinically significant prostate cancer (csPCa) in their initial biopsy. The main questions it aims to answer are: Does lesion progression in bpMRI predict a diagnosis of csPCa in per-protocol follow-up biopsies? What are the radiological and clinical risk factors for csPCa in per-protocol follow-up biopsies?

Conditions

• Prostate Cancer (Diagnosis)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI	Biparametric follow-up prostate MRI and biopsies (systematic and targeted) for all study patients within one year, or earlier if the PSA value measured every three months increases by more than 50% from the baseline level in study inclusion, or if the physician has any other suspicion of high-risk prostate cancer.

Timeline

• Start date: 2026-02-23
• Primary completion: 2027-12-31
• Completion: 2037-12-31
• First posted: 2026-01-27
• Last updated: 2026-02-24

Locations

1 site across 1 country: Finland