NCT07368868

Effect of Initiation of Veno-venous ECMO on Urine Output and Acute Kidney Injury

Effect of Ultraprotective Ventilation After Veno-venous ECMO Initiation on Urine Output and Acute Kidney Injury (VENTURI) - a Retrospective Single Center Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 76 (actual)
• Sponsor: University Hospital, Ghent · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

With this study, the investigators want to find out whether the use of a "lung machine" (extracorporeal membrane oxygenation (ECMO)) togethet with giving the lungs "rest" (by minimizing ventilary support) in people with severe pneumonia has an effect on how well the kidneys work. The investigators will use information that was already collected while patients were staying in the intensive care unit. Patients do not need to do anything additional or undergo any additional procedures for this study.

Detailed description

Some people with severe pneumonia need to be admitted to the intensive care unit. In very serious cases, the lungs may work so poorly that breathing without help is no longer possible. These patients then receive support from a breathing machine (a ventilator). Sometimes even this support is not enough, and a special machine is needed to temporarily take over the function of the lungs. This machine is called a "lung machine" (also known as ECMO). When a patient is connected to this lung machine, the patient's own lungs are exposed to as little pressure and stimulation as possible. This is called "lung rest" and gives the lungs time to heal. In people who are very ill, such as those with severe pneumonia, other organs can also be affected. The kidneys, which are important for making urine and removing waste products from the body, may suddenly stop working as well as they should. This study will examine whether using the lung machine and lung rest affects how the kidneys work.

Conditions

• ARDS (Acute Respiratory Distress Syndrome)
• Acute Kidney Injury
• ECMO

Timeline

• Start date: 2025-12-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2026-01-27
• Last updated: 2026-01-30

Locations

1 site across 1 country: Belgium