NCT07368686

Topical Multivitamin Serum for Skin Heath

A Prospective Clinical Study Evaluating the Effects of a Topical Multivitamin Serum on Facial Skin Hydration and Biophysical Parameters Following Microneedling

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Erevna Innovations Inc. · Academic / Other
• Sex: All
• Age: 22 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Skin boosters are injectable and topical treatments designed to improve dermal quality and restore skin health. These products typically include hyaluronic acid formulations, biostimulatory agents, platelet-rich plasma (PRP), growth factors, and polynucleotides. Their growing use in aesthetic medicine is supported by their diverse mechanisms of action and routes of administration. One such category of interest includes polynucleotide-based therapies, most notably Polydeoxyribonucleotide (PDRN). Derived from the DNA of salmon or trout, PDRN exhibits dual regenerative and anti-inflammatory properties. Mechanistically, it promotes tissue repair by supplying nucleotides essential for DNA synthesis and activates adenosine A2A receptors, thereby enhancing angiogenesis and mitigating inflammation. Clinically, PDRN has been applied in aesthetic medicine for skin rejuvenation, where it improves elasticity, texture, and reduces fine lines, as well as in wound healing and scar remodeling, supporting its integration into advanced bioregenerative protocols. Among such agents, VAMP™ ADVANCED Topical Multivitamin Serum is formulated to improve hydration, elasticity, and overall skin radiance through a proprietary blend of amino acids, vitamins, and peptides. While preliminary data suggest potential benefits, robust peer-reviewed clinical studies remain limited. This study seeks to evaluate the efficacy of topical application of VAMP™ ADVANCED Topical Multivitamin Serum following microneedling in skin rejuvenation.

Conditions

• Aesthetic

Interventions

Type	Name	Description
DEVICE	Microneedeling with topical application of VAMP(TM) ADVANCED Topical Multivitamin Serum	VAMP™ Topical Multivitamin Serum is not indicated for use in pregnancy, lactation, or in individuals under the age of 22. Female participants of childbearing potential will be required to undergo urine pregnancy testing at baseline and prior to each treatment session. They will also be instructed to use an acceptable form of effective contraception for the duration of the study.

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-02-01
• Completion: 2027-03-01
• First posted: 2026-01-26
• Last updated: 2026-02-05

Locations

1 site across 1 country: Canada