NCT07367802

Exploring the Benefits of a 3D Patient-specific Alignment in Total Knee Arthroplasty

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: KU Leuven · Academic / Other
• Sex: All
• Age: 55 Years – 85 Years
• Healthy volunteers: Accepted

Summary

General Aim: to explore the iKA in TKA related to clinical, biomechanical, and functional outcomes.

Detailed description

First specific aim: to investigate the kinematics during daily functional movements in individuals with the iKA TKA to those with aMA TKA, as well as the healthy control group. Second specific aim: to investigate kinetics and muscle activation patterns during functional movements in individuals with the iKA aligned TKA to those with aMA TKA, as well as a healthy control group. Third specific aim: to investigate the impact of the whole body on functional outcomes following iKA and aMA TKA, in comparison to the healthy control group, and to explore the underlying factors contributing to suboptimal outcomes.

Conditions

• TKA Outcomes

Interventions

Type	Name	Description
PROCEDURE	iKA	This study compared inverse kinematic alignment (iKA) TKA, which preserves native JLO, with adjusted mechanical alignment (aMA) TKA, which standardizes JLO to 90°, and a healthy control group across eight functional activities.

Timeline

• Start date: 2024-02-01
• Primary completion: 2027-09-01
• Completion: 2027-09-01
• First posted: 2026-01-26
• Last updated: 2026-01-26

Locations

1 site across 1 country: Belgium