NCT07366645

Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries

Clinical Efficacy and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride to Arrest Incipient Carious Lesions in Permanent Molar Teeth With or Without Application of LED Light: A Randomized Clinical Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 366 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light application on caries arrest of initial enamel pits and fissure caries for permanent teeth of young adults

Conditions

• Incipient Caries

Interventions

Type	Name	Description
OTHER	International Sliver Diamine Fluoride	It is the gold standard; it is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
OTHER	Local brand Egyptian Silver Diamine Fluoride	It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 60 seconds.
OTHER	Silver Fluoride	It is a water-based remineralizing agent with an application time of 60 seconds.
OTHER	International Sliver Diamine Fluoride with LED light	It is an international brand, it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.
OTHER	Local brand Egyptian Silver Diamine Fluoride with LED light	It is a new Egyptian brand of SDF; it is ammonia-based, and it is a remineralizing agent with an application time of 10 seconds, followed by LED application for 20 seconds.
OTHER	Silver Fluoride with LED light	It is a water-based remineralizing agent with an application time of 10 seconds, followed by LED light application for 20 seconds.

Timeline

• Start date: 2026-03-01
• Primary completion: 2027-06-01
• Completion: 2027-07-01
• First posted: 2026-01-26
• Last updated: 2026-01-26