NCT07365566

Pain Assessment in Patients With Idiopathic REM Sleep Behaviour Disorder

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, with over 12 million patients expected globally by 2040. The disease is currently diagnosed at the appearance of motor symptoms, but by then, over 60% of striatal dopaminergic neurons have already been destroyed. Prodromal symptoms such as idiopathic REM Sleep Behavior Disorder (iRBD), anosmia, mood disorders and constipation appear earlier and are listed as criteria for a prodromal PD diagnosis. Identifying early signs is critical to initiate neuroprotective treatments as early as possible. While pain is prevalent and highly disabling in early PD, no data are currently available on pain perception in iRBD patients, whose condition is of the main risk factor for PD development.

Conditions

• REM Sleep Behavior Disorder (iRBD)
• Narcolepsy Type 1

Interventions

Type	Name	Description
OTHER	Thermo test pain	Patients will undergo a pain test, also called a thermotest, which consists of determining pain thresholds using a thermometer applied to the hand.
OTHER	Pain questionnaires	Patients will complete various questionnaires about pain
OTHER	No motors symptoms evaluations	Patients will complete questionnaires

Timeline

• Start date: 2026-02-01
• Primary completion: 2026-08-01
• Completion: 2026-08-01
• First posted: 2026-01-26
• Last updated: 2026-03-03

Locations

1 site across 1 country: France