NCT07364656

Analysis of the Presence and Cardiac Functional Effects of Anti-NaV1.5 Autoantibodies in Patients With Metastatic Tumors

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 196 (estimated)
• Sponsor: IRCCS Policlinico S. Donato · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The overall aim of this study is to identify and characterize anti-NaV1.5 autoantibodies in patients with metastatic breast and colorectal cancer. These tumors are characterized by the presence of a specific target structure (called nNaV1.5) against which antibodies are produced. These antibodies may cross-react with a similar structure (called NaV1.5) that is found in the heart. This could affect channel function and increase the risk of arrhythmias.

Conditions

• Brugada Syndrome (BrS)
• Breast Cancer Females
• Colon Cancer
• ECG Abnormalities
• Autoantibodies Screening

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ECG	These patients require an ECG to exclude the onset of arrhythmias.

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-06-01
• Completion: 2026-12-01
• First posted: 2026-01-23
• Last updated: 2026-01-23

Locations

1 site across 1 country: Italy