NCT07364253

'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial'

Clinical Evaluation Of The Effects Of Propolis Gargle On Wound Healing After Impacted Third Molar Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to examine the effects of propolis gargle on wound healing following third molar surgery and to compare it with chlorhexidine gluconate. The main question it aims to answer is: Is propolis-containing gargle safe and effective alternative to chlorhexidine gluconate following impacted third molar surgery? Does propolis demonstrate comparable outcomes in pain control and mouth opening ?

Detailed description

This prospective, randomized clinical study included 52 healthy patients (ASA I) who underwent impacted mandibular third molar surgery. Patients were randomly allocated into two groups: one group used 0.12% chlorhexidine gluconate gargle, while the other used a 3% propolis-containing gargle. Gargles were applied twice daily for one minute from postoperative day 2 to day 7. Pain was evaluated using the visual analog scale (VAS), while edema, maximum mouth opening, wound healing, and postoperative complications were assessed preoperatively and on postoperative days 2 and 7. Statistical significance was set at p \< 0.05.

Conditions

• Third Molar Surgery
• Post Operative Analgesia

Interventions

Type	Name	Description
PROCEDURE	Third molar Surgery with propolis gargle	The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered a 3% propolis gargle (formulated in an ethanol solution, twice daily for 1 minute, prepared in the Departments of Pharmacology.
PROCEDURE	Third molar surgery with chlorhexidine gluconate	The patients were anesthetized with inferior alveolar, lingual, and buccal nerve blocks using 4 ml of articaine with 1:100,000 epinephrine (Ultracaine D-S Fort, Aventis). The tooth could be observed by elevating a full-thickness triangular mucoperiosteal flap. The tooth was extracted following an osteotomy using a bur. The tooth was sectioned and extracted, if required. Curettage was conducted in the presence of a residual dental follicle. The wound was sutured with silk thread. All procedures were conducted by the same physician. Postoperatively, antibiotics (amoxicillin combined with clavulanic acid, 2 g daily for 5 days) and analgesics (paracetamol 1 g, up to 4 times daily for 3 days) were recommended. The group was administered chlorhexidine gluconate (0.12%) gargle, twice daily for 1 minute.

Timeline

• Start date: 2021-01-05
• Primary completion: 2021-06-03
• Completion: 2022-01-07
• First posted: 2026-01-23
• Last updated: 2026-02-02

Locations

1 site across 1 country: Turkey (Türkiye)