NCT07363421

TMS-Induced LH Response in Healthy Women in Luteal Phase

Feasibility Study Protocol: TMS-Induced LH Response in Healthy Women in the Luteal Phase

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: The City College of New York · Academic / Other
• Sex: Female
• Age: 22 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research is to establish whether non-invasive Transcranial Magnetic Stimulation (TMS), can affect modulation of hormones such: Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH). The hypothesis is that applying TMS to the Dorsolateral Prefrontal Cortex with specific pulse patterns, mimicking endogenous Gonodotropin-Releasing Hormone (GnRH) pulses that are known to stimulate LH secretion may modulate hormonal levels.

Conditions

• Healthy Women

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation Active	Participants will receive stimulation to the left DLPFC. Stimulation intensity will be standardized based on resting motor threshold. Stimulation will be delivered using NeuroStar system.
DEVICE	Transcranial Magnetic Stimulation Sham	Participants will undergo identical procedure to the active TMS group, including coil placement, session duration, and acoustic and somatic sensations. A sham device setting will be used that mimics the sound but does not deliver an effective magnetic field to the DLPFC.

Timeline

• Start date: 2026-02-24
• Primary completion: 2026-05-01
• Completion: 2026-06-01
• First posted: 2026-01-23
• Last updated: 2026-03-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study