NCT07362667

A Study of the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With ABPA

A Prospective, Multicenter, Observational Cohort Study on the Efficacy and Safety of Bronchoscopic Airway Clearance and Amphotericin B Spraying in Patients With Allergic Bronchopulmonary Aspergillosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 44 (estimated)
• Sponsor: Qianfoshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the efficacy and safety of bronchoscopic airway clearance and amphotericin B spraying in the treatment of allergic bronchopulmonary aspergillosis

Conditions

• ABPA
• Allergic Bronchopulmonary Aspergillosis
• Allergic Bronchopulmonary Aspergillosis (ABPA)
• Airway Clearance
• Mucus Plug
• Amphotericin B
• Bronchoscope

Interventions

Type	Name	Description
PROCEDURE	The patients were treated with bronchoscopic airway clearance and amphotericin B spraying	In addition to standard medical therapy (oral glucocorticoids with or without oral antifungal agents), bronchoscopic airway clearance and bronchoscopic spraying of amphotericin B (depending on the effectiveness of bronchoscopic mucus plug removal, At least one time of bronchoscopic airway clearance and amphotericin B spraying). The previous treatment for bronchial asthma was maintained, including inhaled corticosteroids + long-acting β-receptor agonists, leukotriene receptor antagonists, etc.

Timeline

• Start date: 2026-01-10
• Primary completion: 2028-12-31
• Completion: 2028-12-31
• First posted: 2026-01-23
• Last updated: 2026-01-23

Locations

1 site across 1 country: China