Trials / Recruiting
RecruitingNCT07360925
Pericoronary Adipocyte Size Gradient
Direct Measurement of Pericoronary Adipocyte Size Gradient as a Parameter of Immunometabolic Changes of Perivascular Adipose Tissue
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- Institute for Clinical and Experimental Medicine · Other Government
- Sex
- All
- Age
- 30 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.
Detailed description
The project is designed to analyze the impact of inflammation spreading from pericoro-nary adipose tissue to the arterial wall or vice versa. Adipocyte size and immunometabolic parameters gradients established from independent analysis of samples closely adjacent to the coronary artery and those more distant from the arterial lumen will be used to establish the direction of inflammation propagation. The coronary arteries, along with adjacent pericoronary adipose tissue, from explanted hearts will be obtained during heart transplantation of patients with advanced atherosclerosis (ischemic heart disease) and with less advanced atherosclerotic disease (dilated cardiomyopathy). Clinical data (including age, BMI, comorbidities, and concomitant medications) will be recorded. Specifically, previous left ventricular assist device (LVAD) implantation, used as a bridge-to-transplant approach, will be followed to establish the effect of artificial hemodynamic disturbance on coronary artery blood flow on study endpoints.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Heart transplantation for the final stage of heart failure | The study population comprises patients who underwent heart transplantation for heart failure at the Institute for Clinical and Experimental Medicine, Cardiovascular Surgery Department, between June 2023 and December 2028. Only the subjects' retrospective clinical data and matching heart samples will be analyzed. |
Timeline
- Start date
- 2023-06-01
- Primary completion
- 2028-07-01
- Completion
- 2029-07-01
- First posted
- 2026-01-22
- Last updated
- 2026-01-22
Locations
1 site across 1 country: Czechia
Source: ClinicalTrials.gov record NCT07360925. Inclusion in this directory is not an endorsement.