Trials / Recruiting
RecruitingNCT07359690
Multimodal Analysis of Endomyocardial Biopsies
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 216 (estimated)
- Sponsor
- University Hospital, Essen · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and therapy. The main aim is: -Identification of molecular profiles (e.g., proteome, lipidome, metabolome) and immune signalling profiles that are specifically associated with different myocardial diseases and the post-heart transplantation course. Participants already receiving an endomyocardial biopsy as part of their regular medical care will be enrolled. An additional biopsy sample will be taken for the above mentioned research.
Detailed description
The proposed study aims to pursue a multimodal approach to identify the molecular signatures and immune signalling profiles of various myocardial diseases and thereby contribute to improving diagnosis and therapy. In the context of a clinically indicated endomyocardial biopsy (EMB), an additional EMB will be performed. This sample will be further analyzed using, among other methods, multi-omics, immune signalling analysis and nuclear cardiology analyses. These analyses are intended to enable the identification of genetic mutations, inflammatory gene expression patterns, immune signalling and protein alterations in myocardial diseases such as cardiomyopathies, myocarditis, and cardiac amyloidosis. Furthermore, the results will be correlated with established clinical parameters and biomarkers in order to identify novel diagnostic markers.
Conditions
- Heart Transplantation
- Dilated Cardiomyopathy (DCM)
- Hypertrophic Cardiomyopathy (HCM)
- Myocarditis, Pericarditis
- Amyloidosis Cardiac
- Cardiomyopathies
- Sarcoidosis of the Heart
Timeline
- Start date
- 2025-10-27
- Primary completion
- 2028-09-30
- Completion
- 2028-09-30
- First posted
- 2026-01-22
- Last updated
- 2026-01-22
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT07359690. Inclusion in this directory is not an endorsement.