NCT07359664

OCTA in Cardiovascular Disease and Healthy Controls

Optical Coherence Tomography Angiography (OCTA) for the Assessment of Retinal Capillary Density in Patients With Cardiovascular Disease and a Healthy Control Group

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: University of Erlangen-Nürnberg Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy individuals. The study will be conducted at the Clinical Research Centre (CRC), Department of Nephrology and Hypertension at the University of Erlangen-Nuremberg.

Detailed description

Each patient (32 patients) and healthy individual (32 healthy individuals) undergoes one study visit. After providing informed consent, each patient and healthy individual receives an assessment of their retinal vessels using OCTA and SLDF. In the sub-study of 10 patients with cardiovascular disease, the reliability of the OCTA measurements will be determined. Each patient will receive three study visits (with an OCTA and SLDF assessment on each occasion) on three different days.

Conditions

• Patients With Cardiovascular Disease
• Healthy Participants

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Retinal vascular assessment using OCTA and SLDF	Assessment of retinal capillary density using OCTA and SLDF

Timeline

• Start date: 2025-12-01
• Primary completion: 2026-12-01
• Completion: 2027-03-01
• First posted: 2026-01-22
• Last updated: 2026-01-22

Locations

1 site across 1 country: Germany