NCT07356193

Serum CPK and Creatinine Changes During Plyometric Training in Collegiate Athletes

Effects of Lower Body Plyometric Training on Serum Creatine Phosphokinase and Creatinine Levels in Male Collegiate Volleyball Players

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 62 (actual)
• Sponsor: Batterjee Medical College · Academic / Other
• Sex: Male
• Age: 18 Years – 20 Years
• Healthy volunteers: Accepted

Summary

This retrospective study evaluated the effects of an eight-week lower body plyometric training program on serum creatine phosphokinase (CPK) and creatinine levels in male collegiate volleyball players. Sixty two players were divided into experimental and control groups. CPK and creatinine were measured at baseline and multiple time points during training. The study assessed whether plyometric training produced harmful biochemical changes or signs of rhabdomyolysis.

Detailed description

This study evaluated the physiological effects and safety of an eight-week lower body plyometric training program in male collegiate volleyball players, focusing on changes in serum creatine phosphokinase (CPK) and creatinine levels. Sixty two healthy athletes were randomly assigned to either a plyometric training group or a control group. The experimental group performed progressive lower body plyometric exercises twice weekly for eight weeks, while the control group continued regular volleyball training. Serum CPK and creatinine were assessed at baseline and multiple time points throughout the intervention. CPK levels in the training group increased significantly early in the program, peaking on Day 4 and remaining elevated until Week 2, before returning to baseline by Week 8. Importantly, all values remained within normal clinical ranges, and no signs of rhabdomyolysis or overtraining were observed. Serum creatinine levels showed no significant changes, indicating preserved renal function. No biomarker changes were detected in the control group. These findings indicate that an eight-week, progressively designed plyometric training program is safe and well tolerated in male collegiate volleyball players.

Conditions

• Muscle Damage
• Plyometric Exercises
• Creatine Kinase
• Exercise Physiology

Interventions

Type	Name	Description
BEHAVIORAL	Lower Body Plyometric Training	Training twice weekly for eight weeks, including low-, moderate-, and high-intensity plyometric exercises (squat jumps, box jumps, tuck jumps, split squat jumps, lateral hurdle jumps, zigzag jumps, single-leg tuck jumps, and depth jumps).
OTHER	control group	Routine volleyball training only; no plyometric exercises.

Timeline

• Start date: 2022-02-13
• Primary completion: 2022-08-10
• Completion: 2022-12-28
• First posted: 2026-01-21
• Last updated: 2026-01-22

Locations

1 site across 1 country: Saudi Arabia