NCT07355114

Robotic vs Open Nephrectomy for ADPKD

Robotic-assisted Unilateral Nephrectomy for Autosomal Dominant Polycystic Kidney

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 57 (actual)
• Sponsor: University of Bologna · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational prospective cohort study is to evaluate the feasibility, safety, and postoperative outcomes of robotic-assisted unilateral native nephrectomy using the Medtronic Hugo™ RAS system compared with the open surgical approach in patients with autosomal dominant polycystic kidney disease (ADPKD) The main question(s) it aims to answer are: Is robotic-assisted unilateral nephrectomy with the Hugo™ RAS system feasible and safe in patients with ADPKD? Does robotic-assisted nephrectomy provide comparable or improved postoperative outcomes (e.g., complications, transfusion rates, length of hospital stay) compared with open nephrectomy? Researchers will compare robotic-assisted unilateral nephrectomy (Hugo™ RAS) with open unilateral nephrectomy to see if the robotic approach results in similar morbidity with shorter hospital stay, despite longer operative times. Participants are adult patients with ADPKD undergoing unilateral native nephrectomy at a single tertiary transplant center, most of whom have end-stage renal disease and are candidates for or recipients of kidney transplantation. Both male and female patients were included; patients undergoing bilateral nephrectomy were excluded.

Conditions

• Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Timeline

• Start date: 2023-01-01
• Primary completion: 2025-08-30
• Completion: 2028-01-01
• First posted: 2026-01-21
• Last updated: 2026-01-21

Locations

1 site across 1 country: Italy