Trials / Recruiting
RecruitingNCT07354646
The Application of T1 Mapping in Real-World
The Landscape of T1 Mapping for Disease Profiling in a Real-World Cohort
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 2,000 (estimated)
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Accepted
Summary
The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions. We aim to establish reference values for how heart tissue characteristics vary in various diseases, which will help doctors better interpret these advanced MRI measurements in clinical practice. The main questions it aims to answer are: What are the normal T1 mapping values for different heart diseases, and how do they compare to healthy hearts? Can we use the simpler "native T1" measurement (without contrast dye) instead of the more complex "ECV" measurement (which requires contrast dye) for diagnosis? Patients with various myocardial conditions will undergo CMR T1 mapping scans. We will analyze the MRI images and clinical records to establish disease-specific reference ranges for T1 mapping parameters, and validate the diagnostic accuracy of T1 mapping
Conditions
- Myocardial Infarction (MI)
- Hypertrophic Cardiomyopathy (HCM)
- Dilated Cardiomyopathy (DCM)
- Arrhythmogenic Cardiomyopathy
- Myocarditis
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Magnetic Resonance Imaging with Contrast | Participants in this arm undergo a single, standardized cardiac MRI scan with gadolinium-based contrast agent. |
Timeline
- Start date
- 2020-03-01
- Primary completion
- 2026-10-01
- Completion
- 2026-12-01
- First posted
- 2026-01-21
- Last updated
- 2026-01-21
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT07354646. Inclusion in this directory is not an endorsement.