Trials / Not Yet Recruiting

Not Yet RecruitingNCT07353736

Cerebral Arteriovenous Malformation With Aneurysm: Epidemiology, Clinical Features, and Prognosis

Hemodynamic Mechanisms, Clinical Profiles, and Prognostic Factors in Patients With Cerebral Arteriovenous Malformations and Intracranial Aneurysms: An Observational Cohort Study

Status: Not Yet Recruiting
Phase: —
Study type: Observational
Enrollment: 630 (estimated)

Sponsor: Duan Chuanzhi · Academic / Other
Sex: All
Age: —
Healthy volunteers: Not accepted

Summary

The study is a multicenter, prospective cohort study designed to assess the natural history, clinical safety and efficacy of various treatment strategies in patients with cerebral arteriovenous malformations (AVMs) and intracranial aneurysms.

Detailed description

This study aims to evaluate the clinical safety and efficacy of different treatment strategies in patients with cerebral arteriovenous malformations (AVMs) combined with intracranial aneurysms (IAs) through a multicenter, large-sample, prospective observational cohort study. It will comprehensively analyze the epidemiological characteristics, clinical manifestations, associated risk factors, natural disease progression, and bleeding risks, as well as explore the hemodynamic mechanisms and genetic background differences. Clinical data, imaging findings, and blood samples will be collected from patients to investigate the impact of hemodynamics on aneurysm formation, rupture risk, and treatment outcomes. Additionally, the study will explore the genetic differences of AVM and IA patients and their correlation with clinical presentation and prognosis, ultimately providing a scientific basis for individualized treatment strategies.

Conditions

Timeline

Start date: 2026-02-01
Primary completion: 2030-11-30
Completion: 2030-12-30
First posted: 2026-01-20
Last updated: 2026-01-20

Locations

1 site across 1 country: China

Source: ClinicalTrials.gov record NCT07353736. Inclusion in this directory is not an endorsement.