NCT07353502

miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction

Effects of miR-342-5p/AnkG Pathway-Mediated Axon Initial Segment Filtering Injury on Early Synaptic Dysfunction in Alzheimer's Disease and Its Clinical Applications

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities. Current research has found that in the early stages of the disease, synaptic connections between brain nerve cells become abnormal, but the specific cause is still unclear. Investigators' previous research discovered that in the brains of diseased mice, certain special substances (the miR 342 5p/AnkG-mediated pathway) might be related to this abnormality, and these substances can be detected in both blood and cerebrospinal fluid. Therefore, investigators want to further explore the specific mechanisms of abnormal nerve cell connections, seek biomarkers for early detection of the disease, and provide new ideas for early diagnosis in the future.

Conditions

• Alzheimer Disease
• Biomarker in Early Diagnosis

Interventions

Type	Name	Description
OTHER	Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid.	Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid.

Timeline

• Start date: 2025-06-20
• Primary completion: 2026-03-10
• Completion: 2026-03-10
• First posted: 2026-01-20
• Last updated: 2026-01-20

Locations

1 site across 1 country: China