NCT07352982

Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea

Effect of Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: Female
• Age: 20 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the effects of transcutaneous tibial nerve stimulation (TTNS) on women with primary dysmenorrhea (PD).

Detailed description

Dysmenorrhea is defined as painful menstrual cramps of uterine origin, and considered as one of the most common gynecological disorders among females of childbearing age. Primary dysmenorrhea (PD) typically manifests within 6-12 months following menarche. It is not associated with organic lesions but is primarily attributed to uterine smooth muscle spasms and vasoconstriction, which are induced by elevated prostaglandin levels. Additionally, the use of transcutaneous tibial nerve stimulation (TTNS), which consists of the stimulation of the posterior tibial nerve in the superomedial region of the ankle, may be a promising treatment option. The hypogastric sympathetic plexus (L4-L5) and the pelvic parasympathetic plexus (S2-S4) have the same medullar level as the posterior tibial nerve (L4-S3). Thus, inhibitory and excitatory impulses that control the function of the pelvic viscera at the level of the spinal cord can be rebalanced with their stimulation.

Conditions

• Transcutaneous Tibial Nerve Stimulation
• Women
• Primary Dysmenorrhea

Interventions

Type	Name	Description
OTHER	Transcutaneous tibial nerve stimulation (TTNS)	Patients will receive the transcutaneous tibial nerve stimulation (TTNS) and traditional treatment (Nonsteroidal anti-inflammatory drugs) for three sessions a week for four consecutive weeks.
DRUG	Traditional treatment (Nonsteroidal anti-inflammatory drugs)	Patients will receive the placebo transcutaneous tibial nerve stimulation (TTNS) and traditional treatment (Nonsteroidal anti-inflammatory drugs) for three sessions a week for four consecutive weeks.

Timeline

• Start date: 2026-01-19
• Primary completion: 2026-07-01
• Completion: 2026-07-01
• First posted: 2026-01-20
• Last updated: 2026-01-21

Locations

1 site across 1 country: Egypt