NCT07351955

Clinical Study on a Novel Strategy of Individualized Non-Invasive Neuromodulation for the Treatment of Tic Disorders in Children

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Shanghai Children's Medical Center · Academic / Other
• Sex: All
• Age: 5 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to establish a novel personalized closed-loop NiBS/TMS therapeutic strategy and clinical protocol for children with Tic Disorders (TDs) through a series of scientific investigations. Additionally, it seeks to elucidate the underlying neural circuit mechanisms, enhance the therapeutic efficacy of TMS in pediatric TDs, and achieve precision neuromodulation for children with TDs.

Conditions

• Tic Disorders

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	Transcranial magnetic stimulation (TMS) will be administered to the child using a ZL-N-010 model device, targeting predefined sites in the prefrontal, bilateral temporal, and parietal lobes.
BEHAVIORAL	general behavioral therapy	Behavioral interventions include avoiding screen time, parental avoidance of scolding or corporal punishment, and steering clear of activities or emotional stimuli that may exacerbate symptoms.

Timeline

• Start date: 2025-06-01
• Primary completion: 2026-05-31
• Completion: 2026-05-31
• First posted: 2026-01-20
• Last updated: 2026-01-20

Locations

1 site across 1 country: China