NCT07348978

Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris

Efficacy of Auricular Acupressure Combined With 0.1% Adapalene in the Treatment of Acne Vulgaris

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Not accepted

Summary

Acne vulgaris is a common chronic inflammatory skin condition that can significantly affect quality of life. Standard treatments such as topical retinoids are effective but may not fully control symptoms in all patients. This study evaluated the effectiveness of auricular acupressure combined with topical 0.1% adapalene compared with topical 0.1% adapalene alone in patients with acne vulgaris. Auricular acupressure is a non-invasive traditional medicine technique that may help regulate inflammatory responses and improve skin conditions. The objective of this study was to determine whether the combination therapy provides greater improvement in acne severity and clinical outcomes than standard topical treatment alone.

Detailed description

Acne vulgaris is a multifactorial inflammatory skin disease commonly affecting adolescents and young adults. Although topical retinoids such as adapalene are widely used and effective, some patients experience incomplete responses or persistent symptoms. Auricular acupressure is a traditional therapeutic method that involves stimulating specific points on the ear and has been used to support systemic regulation and inflammatory control. This study was designed to explore the potential added benefit of auricular acupressure when combined with standard topical adapalene therapy. This interventional study compared two treatment approaches in patients with acne vulgaris: auricular acupressure combined with topical 0.1% adapalene versus topical 0.1% adapalene alone. Participants were assigned to treatment groups according to the study protocol and followed for clinical assessment. The primary objective of the study was to evaluate the effectiveness of the combination therapy in improving acne severity and overall clinical outcomes compared with standard treatment alone.

Conditions

• Acne Vulgaris

Interventions

Type	Name	Description
OTHER	Auricular Acupressure	Auricular acupressure was performed by applying pressure to specific auricular points according to traditional medicine principles. The intervention was administered as an adjunctive therapy in combination with topical adapalene.
DRUG	Adapalene 0.1% Gel	Topical adapalene 0.1% was applied to affected areas once daily as standard treatment for acne vulgaris.

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-06-30
• Completion: 2025-11-10
• First posted: 2026-01-16
• Last updated: 2026-01-16

Locations

1 site across 1 country: Vietnam