NCT07348770

Cold Plasma Effects on Dental Implant Stability

Effect of Different Cold Plasma Systems on Dental Implant Stability: A Randomized Controlled Split-Mouth Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Kahramanmaras Sutcu Imam University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cold plasma-mediated implant surface activation may reverse the biological aging of titanium by enhancing hydrophilicity and cellular response. The aim of this study was to clinically compare the effects of three different cold plasma systems on the stability of dental implants. In this prospective randomized controlled split-mouth study, a total of 44 implants were placed in 11 patients. In each patient, four implants were randomly allocated to one of the following groups: control, vacuum plasma, argon jet plasma, and cold atmospheric plasma. All implants were placed using a single-stage protocol with a minimum insertion torque of 45 Ncm. Implant stability was assessed using resonance frequency analysis (ISQ values) immediately after placement and at 2, 4, and 8 weeks.

Conditions

• Cold Atmospheric Plasma
• Dental Implants

Interventions

Type	Name	Description
PROCEDURE	Dental implant placement	The dental implant was placed without any plasma application.
PROCEDURE	Dental implant placement and vacuum plasma application	The dental implant was placed with non-thermal low-pressure cold plasma application
PROCEDURE	Dental implant placement and argon jet plasma application	The dental implant was placed with argon jet plasma application
PROCEDURE	Dental implant placement and cold atmospheric plasma application	The dental implant was placed with cold atmospheric plasma application

Timeline

• Start date: 2025-02-24
• Primary completion: 2025-07-08
• Completion: 2025-09-09
• First posted: 2026-01-16
• Last updated: 2026-01-16

Locations

1 site across 1 country: Turkey (Türkiye)