NCT07348614

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

Flex Appeal: A Prospective Randomized Controlled Trial Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (MUA)

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 128 (estimated)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine if changing the type of anesthesia improves the outcomes of manipulation and pain control after the procedure. The study will compare a spinal anesthesia with a general anesthesia, to see if there is a better outcome from either anesthesia type.

Conditions

• Knee Stiffness After Total Knee Arthroplasty

Interventions

Type	Name	Description
PROCEDURE	Spinal Anesthesia	Administration of spinal anesthesia for knee manipulation.
PROCEDURE	General Anesthesia	Administration of general anesthesia for knee manipulation.
DRUG	Propofol	Patients undergoing general anesthesia will receive an induction dose of propofol that will be titrated to effect, and airway support as needed until the patient is appropriately anesthetized for the procedure as determined by the anesthesia and surgical care teams.
DRUG	Chloroprocaine	Patients undergoing spinal anesthesia will receive a spinal injection under standard aseptic technique, with 45mg chloroprocaine.

Timeline

• Start date: 2026-03-01
• Primary completion: 2027-08-01
• Completion: 2027-09-01
• First posted: 2026-01-16
• Last updated: 2026-01-16

Regulatory

• FDA-regulated drug study