NCT07348510

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures

Comparison Between the Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures: A Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 106 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.

Detailed description

Acute Kidney injury (AKI) is a serious and common complication after either adult or pediatric cardiac surgery. The results of a recent meta-analysis suggested that loop diuretics (furosemide) may reduce postoperative creatinine clearance, whereas aldosterone agonists (spironolactone) increase the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI). Diuretics are not recommended for the prevention of AKI, but loop diuretics may be used for the management of volume overload Aminophylline in cardiac surgery can reduce the frequency of AKI and could be used in the prevention of AKI as a safe and efficient modality in high-risk patients.

Conditions

• Diuretic Effect
• Aminophylline
• Furosemide
• Cardiac Surgical Procedures

Interventions

Type	Name	Description
DRUG	Aminophylline	Patients will receive Aminophylline.
DRUG	Furosemide	Patients will receive furosemide.

Timeline

• Start date: 2026-01-17
• Primary completion: 2026-07-26
• Completion: 2026-07-26
• First posted: 2026-01-16
• Last updated: 2026-01-21

Locations

1 site across 1 country: Egypt