NCT07348328

Vitamin B Supplementation for Patients Undergoing Cardiovascular Surgery

Vitamin B Supplementation for Patients Undergoing Cardiovascular Surgery: A Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (estimated)
• Sponsor: Nanjing Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study is a multicenter, randomized controlled, double-blind, placebo-controlled parallel trial designed to evaluate the effect of perioperative supplementation with Compound Vitamin B on patients undergoing cardiovascular surgery. A total of 1,000 patients aged 18-80 years who are scheduled to receive cardiovascular surgeries such as coronary artery bypass grafting (CABG) and valve replacement will be enrolled. They will be randomly assigned at a 1:1 ratio to either the experimental group (perioperative supplementation with Compound Vitamin B tablets, once daily from 3 days before surgery to 6 months after surgery) or the control group (oral placebo), with both groups receiving standardized perioperative treatment.

Conditions

• Cardiovascular Surgical Procedures
• Major Adverse Cardiovascular Events (MACE)

Interventions

Type	Name	Description
DRUG	Compound Vitamin B tablet	perioperative supplementation with Compound Vitamin B tablets, once daily from 3 days before surgery to 6 months after surgery
DRUG	Control	perioperative supplementation with placebo, once daily from 3 days before surgery to 6 months after surgery

Timeline

• Start date: 2026-02-01
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2026-01-16
• Last updated: 2026-01-16

Locations

2 sites across 1 country: China