NCT07347925

Effect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEF

Evaluating the Impact of Pre-Hospital Angiotensin Receptor-Neprilysin Inhibitor (ARNI) Therapy on Short-Term Clinical Outcomes in Heart Failure Patients With Reduced Ejection Fraction: A Comparative Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 140 (estimated)
• Sponsor: Future University in Egypt · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study looks at people with heart failure who are admitted to the hospital. The goal of the study is to understand whether taking a heart failure medicine called angiotensin receptor-neprilysin inhibitor (ARNI) before hospital admission affects short-term health outcomes. The study will compare two groups of participants: those who were already taking ARNI before coming to the hospital and those who were not. Information will be collected from medical records during the hospital stay, including heart-related events, kidney-related events, and how long participants stay in the hospital. Some participants will also be followed for a short period after discharge. This study may help improve understanding of outcomes associated with ARNI use in people with heart failure in routine clinical care.

Conditions

• Heart Failure

Interventions

Type	Name	Description
OTHER	Prehospital ARNI use	Participants who were using ARNI therapy before hospital admission
OTHER	No prehospital ARNI use	Participants who were not using ARNI therapy before hospital admission

Timeline

• Start date: 2026-01-10
• Primary completion: 2026-04-15
• Completion: 2026-05-01
• First posted: 2026-01-16
• Last updated: 2026-01-16

Locations

1 site across 1 country: Egypt