NCT07346573

Radiotherapy Safety for Liver Malignancies Using Post-Treatment Imaging

A Retrospective Single-Center Study Utilizing AI-Based Radiomics on Pre- and Post-Radiotherapy CT Images to Explore the Safety Dose Threshold in Liver Malignancy Radiation Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 274 (actual)
• Sponsor: Cao peiguo · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The goal of this retrospective observational study is to investigate the safety of radiation therapy for liver malignancies by analyzing data from patients who have already completed this treatment . The main questions it aims to answer are: What is the specific radiation dose level that leads to a visible change on CT scans called a Focal Liver Reaction (FLR)? Why do some patients develop these imaging changes while others do not, based on their scan features and clinical information? Researchers will compare patients who developed FLR with those who did not to identify the factors associated with this reaction. This study uses existing medical records and images; therefore, participants will not need to undergo any new interventions or procedures.

Conditions

• Liver Neoplasms
• Radiation-Induced Liver Injury

Interventions

Type	Name	Description
OTHER	Clinically Delivered Radiation Therapy (e.g., SBRT/IMRT) for Liver Cancer	This is a retrospective observational study. The intervention (radiotherapy) was administered as part of standard clinical care prior to the study. Researchers are analyzing the outcomes of this previously delivered intervention.

Timeline

• Start date: 2019-05-01
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2026-01-16
• Last updated: 2026-01-16

Locations

1 site across 1 country: China