NCT07341698

Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Al-logeneic Hematopoietic Stem Cell Transplantation

Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Alloge-neic Hematopoietic Stem Cell Transplantation - a National Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (estimated)
• Sponsor: Rigshospitalet, Denmark · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Seventy-five percent of patients treated with hematopoietic stem cell transplants survive one-year post-transplantation. However, this intensive treatment is associated with prolonged hospitalizations and significant deconditioning. Pathophysiological changes in skeletal muscle mass and function have notable implications for disease progression and long-term prognosis. Patients frequently report substantial rehabilitation needs, though these needs are highly individualized and fluctuate over time, with musculoskeletal dysfunction and fa-tigue being the most common barriers to prehabilitation. Furthermore, at least 35% of cancer patients are found to have inadequate daily protein intake, which may hinder improve-ments in physical performance through prehabilitation. Several recent studies have demonstrated the safety and feasibility of exercise-based prehabilitation interventions during the pre-transplant period. However, no full-scale randomized controlled trial (RCT) has been conducted to date.

Detailed description

Evaluate the effectiveness of an individualized prehabilitation intervention in addition to usual care, compared to usual care alone on HRQoL, and secondary outcomes hospitalization, muscle mass and muscle function.

Conditions

• Allogeneic Hematopoietic Stem Cell Transplantation Recipient

Interventions

Type	Name	Description
OTHER	Resistance training	Structured and supervised, group-based, resistance training 3x per week (individually tailored to the individual's capabilities)
DIETARY_SUPPLEMENT	Nutritional Support	Optimized dietary counseling and supplementation to optimize nutritional intake
PROCEDURE	Usual care	Usual care is the standard care before allogeneic hematopoietic stem cell transplantation

Timeline

• Start date: 2026-01-12
• Primary completion: 2028-01-12
• Completion: 2032-10-12
• First posted: 2026-01-14
• Last updated: 2026-01-29

Locations

1 site across 1 country: Denmark