NCT07341412

Clinical and Genetic Aspects in Fetuses and Children With Sex Chromosome Disorders

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 0 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The aim of the project is to: 1. Investigate organ development and growth in fetuses with sex chromosome disorders; 2. Investigate growth, development, and morbidity in children with sex chromosome disorders during the first years of life; 3. Delineate how variations in sex chromosome number affect the epigenetic and genetic mechanisms regulating gene expression in the placenta and in multiple tissues of the child after birth over time during early childhood; 4. Investigate the gut microbiome in children with sex chromosome disorders during the first years of life; 5. Identify the epigenetic and genetic mechanisms and placental and child-specific alterations underlying the phenotype observed in fetuses, children, and adults with sex chromosome disorders, using a deep phenotyping approach.

Conditions

• Sex Chromosome Disorders

Timeline

• Start date: 2024-09-01
• Primary completion: 2034-01-01
• Completion: 2034-01-01
• First posted: 2026-01-14
• Last updated: 2026-01-14

Locations

1 site across 1 country: Denmark