NCT07341269

Urinary NGAL and KIM-1 After ESWL

Prospective Evaluation of the Effect of Different Intervals Between Extracorporeal Shock Wave Lithotripsy (ESWL) Sessions on Potential Renal Injury Using Urinary NGAL and KIM-1 Biomarkers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Marmara University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this prospective observational study is to evaluate the effect of different time intervals between extracorporeal shock wave lithotripsy (ESWL) sessions on renal injury using urinary biomarkers in patients with urinary system stone disease. The main questions it aims to answer are: Does the interval between consecutive ESWL sessions affect the degree of renal injury? Are urinary NGAL and KIM-1 levels reliable biomarkers for detecting ESWL-related renal damage? What is the optimal time interval between ESWL sessions to minimize renal injury? If there is a comparison group, researchers will compare patients undergoing ESWL with different inter-session time intervals to determine whether shorter or longer intervals are associated with higher levels of renal injury biomarkers. Participants will: Undergo ESWL treatment for urinary system stones Be assigned to one of two groups based on the time interval between ESWL sessions Provide urine samples before ESWL and after three ESWL sessions Have urinary NGAL and KIM-1 levels measured to assess renal injury

Conditions

• Urinary Stone
• Renal Injury

Interventions

Type	Name	Description
OTHER	No Interventions	No study-specific intervention; patients receive standard-of-care SWL.
OTHER	No intervention	No study-specific intervention; patients receive standard-of-care SWL.

Timeline

• Start date: 2025-06-01
• Primary completion: 2025-08-01
• Completion: 2025-12-10
• First posted: 2026-01-14
• Last updated: 2026-01-14

Locations

1 site across 1 country: Turkey (Türkiye)