NCT07340125

Pistachio Snacking and Metabolic Flexibility

Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University of South Carolina · Academic / Other
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.

Conditions

• Overweight (BMI > 25)
• Obese But Otherwise Healthy Participants
• Overweight or Obese
• Obese Patients (BMI ≥ 30 kg/m²)
• Poor Sleep Quality
• Healthy Participants
• Physically Inactive

Interventions

Type	Name	Description
OTHER	Pistachio	Roasted, lightly salted, pistachio kernels (no shell)

Timeline

• Start date: 2025-09-01
• Primary completion: 2026-08-01
• Completion: 2026-12-31
• First posted: 2026-01-14
• Last updated: 2026-01-14

Locations

1 site across 1 country: United States