NCT07336251

Transcranial Magnetic Stimulation in Veterans With PTSD

Transcranial Magnetic Stimulation in Veterans With PTSD: A Pilot Study to Examine Mechanism of Effect

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: White River Junction Veterans Affairs Medical Center · Federal
• Sex: All
• Age: 19 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

With this research investigators hope to begin to understand how rTMS can improve posttraumatic stress disorder (PTSD) symptoms. TMS improves PTSD through two interrelated mechanisms: change in brain limbic system function and change in systemic inflammatory activation. Participants who decide to join this study, will receive ten rTMS treatments. All participants will undergo a 40-minute rTMS procedure with a member of the study team 10 times over 2-4 weeks. Participants will undergo fMRI scans of the head in order to help researchers better understand potential effects of rTMS on brain activity. In addition, participants will be asked to give two breath and blood samples to look for signs of general inflammation.

Conditions

• PTSD - Post Traumatic Stress Disorder

Interventions

Type	Name	Description
DEVICE	Transcranial Magnetic Stimulation	10 sessions of low frequency rTMS (1Hz) applied to the right dorsolateral prefrontal cortex.

Timeline

• Start date: 2026-01-15
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2026-01-13
• Last updated: 2026-01-21

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study