NCT07333755

New Technique of End-to-Side Two-Layered Duct-to-Mucosa Pancreaticojejunostomy With Omental Wrapping and Glue (Glubran 2) During Laparoscopic Whipple Operation

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Theodor Bilharz Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Following pancreaticoduodenectomy, omental flaps around the pancreatic anastomosis and adhesive glue can lower the risk of pancreatic fistula, post-pancreatectomy bleeding, and delayed gastric emptying. The overall morbidity following pancreaticoduodenectomy can be decreased with this straightforward and efficient treatment.

Conditions

• Periampullary Carcinoma Resectable

Interventions

Type	Name	Description
PROCEDURE	Pancreaticojejunostomy without omental patch	A laparoscopic pancreaticoduodenectomy with pylorus preservation was performed on each patient. A pancreatojejunostomy was created and not fixed with an omental patch or glue.
PROCEDURE	Pancreaticojejunostomy with omental patch and glue	A laparoscopic pancreaticoduodenectomy was performed on each patient. A pancreaticojejunostomy was fixed with glue to secure the anastomosis. The greater omentum was separated longitudinally over an avascular zone, and one or two omental branches of the gastroepiploic arteries were preserved using pedicle omental flaps. The omentum was rolled up and secured with glue.

Timeline

• Start date: 2023-11-05
• Primary completion: 2025-11-05
• Completion: 2025-11-05
• First posted: 2026-01-12
• Last updated: 2026-01-12

Locations

1 site across 1 country: Egypt