NCT07330661

Nursing-Led Deep Vein Thrombosis Prevention in Neurosurgery

Neurointerdisciplinary Nursing Prevention Strategies for Deep Vein Thrombosis (DVT) After Neurosurgical Procedures: A Multicenter Randomized Controlled Trial and Nomogram Development

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,286 (actual)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to see if a nurse-led program (early movement, leg-sleeve squeezes, and blood tests) can prevent dangerous leg blood clots in adults who have just had brain or spine surgery. Main questions it aims to answer: * Does the program lower the number of clots within 30 days after surgery? * Is the program safer and more accurate than the usual clot-risk score nurses already use? Researchers will compare patients who receive the nurse-led program with patients who receive standard hospital care. Participants will: * Be randomly assigned to one of the two groups. * Have regular leg ultrasounds to check for clots. * Wear a small activity tracker if they are in the nurse-led group.

Conditions

• Deep Vein Thrombosis (DVT)

Interventions

Type	Name	Description
BEHAVIORAL	nurse-led program (early movement, leg-sleeve squeezes, and blood tests)	Graded early-movement plan starting within 24 h of surgery * Unconscious patients: passive leg exercises 10-15 min, 3× daily * Conscious patients: assisted leg, sitting and walking sessions escalated daily (target ≥ 40 min total activity, logged automatically by a wrist-band activity tracker) Intermittent pneumatic compression (IPC) * 2 h/session, 2× daily, 30-45 mmHg while in bed, continued until independent walking D-dimer blood checks on post-op days 1, 3, 7 and 14; any rise ≥ 20 % or level \> 2 mg/L triggers an extra leg ultrasound Continuous safety watch (heart rate, blood pressure, intracranial pressure if monitored); IPC or movement is paused if pressure \> 20 mmHg or vital signs become unstable

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-12-30
• Completion: 2024-05-01
• First posted: 2026-01-09
• Last updated: 2026-01-12

Locations

1 site across 1 country: China