NCT07330401

Assessment of Cytotoxicity, Genotoxicity

Assessment of Cytotoxicity, Genotoxicity in Exfoliated Buccal Mucosa Cells Following Exposure to OPG and CBCT Radiations: A Comparative Study Across Age Groups

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Yaxin Wang · Academic / Other
• Sex: All
• Age: 15 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Goal: The goal of this observational study is to evaluate the genotoxic and cytotoxic effects of OPG and CBCT on exfoliated buccal mucosal cells Main question: Does CBCT cause greater genotoxic and cytotoxic effects on buccal mucosal cells compared with OPG? Buccal epithelial cells were gently exfoliated from participants scheduled to undergo OPG or CBCT imaging. Samples were collected twice-immediately before exposure and again 10-12 days afterward. All participants provided written informed consent prior to inclusion in the study.

Conditions

• Genotoxicity
• Cytotoxicity
• Ionizing Radiation Exposure
• Dental X-Ray Exposure

Timeline

• Start date: 2024-10-01
• Primary completion: 2025-07-01
• Completion: 2025-09-30
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: Malaysia