NCT07330375

Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia

The Effect of Intravenous Combination Dexmedetomidine - Ketamine Versus Dexmedetomidine on Post-Operative Analgesia in Patients Undergoing Vaginal Hysterectomy Under Spinal Anesthesia

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Zagazig University · Other Government
• Sex: Female
• Age: 21 Years – 65 Years
• Healthy volunteers: Accepted

Summary

In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine \_ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.

Conditions

• Postoperative Analgesia
• Postoperative Pain Management

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Intravenous dexmedetomidine 0.5 µg/kg diluted with normal saline to a volume of 10 ml solution over 10 min followed by 0.5 µg/kg/h infusion.
DRUG	Ketamine	Intravenous ketamine 0.2 mg/kg diluted with normal saline to a volume of 10 ml solution over 2-3 min followed by 0.2 mg/kg/hr infusion.
DRUG	Saline (0.9% NaCl)	intravenous normal saline 10ml of solution over 2-3min followed by 0.2 mg/kg/hr infusion as placebo

Timeline

• Start date: 2026-01-20
• Primary completion: 2026-06-15
• Completion: 2026-06-30
• First posted: 2026-01-09
• Last updated: 2026-01-09