NCT07329907

Combination Therapy for Warts: Candida Antigen vs. Topical Keratolytic

Comparative Efficacy of Topical Salicylic Acid/Lactic Acid, Intralesional Candida Antigen, and Their Combination in the Treatment of Warts: A Randomized, Assessor-Blinded, Controlled Trial

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 126 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 5 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Objective: To compare the efficacy, safety, and recurrence rates of topical salicylic acid/lactic acid (SA/LA) monotherapy (Group A), intralesional Candida antigen (CA) monotherapy (Group B), and their combination (Group C) for the treatment of warts.

Conditions

• Warts
• Human Papilloma Virus (HPV)

Interventions

Type	Name	Description
DRUG	Salicylic Acid/Lactic Acid Topical Solution	Patients receive topical application of Salicylic Acid 40% and Lactic Acid 16% once daily for up to 6 weeks.
BIOLOGICAL	Candida Antigen Intralesional Injection	Patients receive intralesional injection of Candida Antigen (0.1-0.3 mL) every 2 weeks for up to 6 sessions.
COMBINATION_PRODUCT	Candida Antigen and Salicylic Acid/Lactic Acid	Patients receive intralesional injection of Candida Antigen (0.1-0.3 mL) every 2 weeks for up to 6 sessions, with topical Salicylic Acid 40% and Lactic Acid 16% applied in between.

Timeline

• Start date: 2023-12-01
• Primary completion: 2024-06-01
• Completion: 2024-12-30
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: Egypt