NCT07329725

Genetic Drivers,Risk Factors and Management Strategies on Survival and Clinical Outcomes in Visceral Venous "Thrombosis"

Impact of Genetic Drivers, Acquired Risk Factors, and Management Strategies on Survival and Clinical Outcomes in Visceral Venous Thrombosis

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 101 (estimated)
• Sponsor: Sohag University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design.

Detailed description

Observational study (hybrid study comprising a retrospective and prospective cohort analysis): To evaluate the impact of genetic drivers (somatic and inherited thrombophilias), acquired risk factors, and management strategies on survival and clinical outcomes in patients with VVT using a hybrid prospective-retrospective cohort design. Data will be collected from the Department of Internal Medicine/hematology unit at Sohag University hospital and clinical databases. The retrospective component will include eligible patients diagnosed within the preceding ten years, whereas the prospective component will enroll newly diagnosed patients and follow them for one year. 1. Retrospective Cohort Analysis: Review of medical records to analyze demographic, clinical, and molecular data. Assessment of treatment regimens and outcomes, including thrombotic events, disease progression, and survival rates. 2. Prospective Cohort Analysis: Consecutive patients will be diagnosed with VVT from \[date of ethical approval\] forward, enrolled at diagnosis and followed prospectively with standardized baseline testing (including comprehensive genetic panel) and predefined follow-up visits.

Conditions

• Visceral Venous Thrombosis

Interventions

Type	Name	Description
OTHER	Doppler ultrasonography	Radiological intervention Basic laboratory investigations, and Thrombophilia diagnosis

Timeline

• Start date: 2025-12-14
• Primary completion: 2026-12-14
• Completion: 2026-12-14
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: Egypt