NCT07329686

Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.

• Status: Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Corneal stromal injection is an emerging local drug delivery method, characterized by strong targeting, high drug concentration, and prolonged duration of action. It has been preliminarily applied in the treatment of fungal keratitis and neurotrophic corneal diseases. This study aims to investigate the safety and efficacy of anti-VEGF drugs delivered via corneal stromal injection in neovascularization caused by HSK (Herpes Simplex Keratitis). The study has clear medical significance and technical feasibility, and it is expected to promote innovation in the treatment paradigm for corneal neovascularization.

Conditions

• Herpes Simplex Keratitis
• Corneal Neovascularization

Interventions

Type	Name	Description
DRUG	Intrastromal anti-VEGF injection and topical antiviral eye drops	The experimental group received intrastromal corneal injections of anti-VEGF (Vascular Endothelial Growth Factor) medication in conjunction with antiviral medication therapy
DRUG	Conventional antiviral topical ocular drops.	The control group was treated with conventional antiviral topical ocular drops.

Timeline

• Start date: 2025-10-01
• Primary completion: 2026-10-01
• Completion: 2026-10-01
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: China