NCT07329062

Effect of Toothpastes on Oral Malodor

Investigation of the Effect of Toothpastes With Different Ingredients on Oral Malodor in Young Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: Çankırı Karatekin University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study aimed to evaluate the effects of different toothpaste formulations on oral malodor in young adults, addressing the lack of clinical evidence regarding propolis- and probiotic-containing toothpastes, which have predominantly been investigated in mouthrinse, tablet, or chewing gum formulations. Volunteers aged 18-30 years with baseline organoleptic assessment (OA) and Breath Checker® (BC) scores \>0 were randomized into four toothpaste groups: propolis-containing (Glimo Beta), probiotic-containing (Glimo Pi), phosphate-based (Glimo Gamma), and a standard fluoride toothpaste (Sensodyne). Allocation concealment was ensured using identical coded containers, and outcome assessors were blinded. After exclusions, 52 participants completed the study. Oral malodor was evaluated at baseline (T0) and Day 14 (T1) using OA, BC measurements, and self-perceived oral malodor scores.

Conditions

• Oral Malodor (Halitosis)

Interventions

Type	Name	Description
OTHER	Propolis Containing Toothpaste	Participants were instructed to brush their teeth using propolis toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
OTHER	Probiotic containing toothpaste	Participants were instructed to brush their teeth using probiotic toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
OTHER	Phosphate-based formulation toothpaste	Participants were instructed to brush their teeth using Phosphate-based formulation toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.
OTHER	Standard fluoride toothpaste	Participants were instructed to brush their teeth using standard fluoride toothpaste twice daily (morning and evening) for 14 days as part of their routine oral hygiene.

Timeline

• Start date: 2025-01-30
• Primary completion: 2025-06-30
• Completion: 2025-12-25
• First posted: 2026-01-09
• Last updated: 2026-01-09

Locations

1 site across 1 country: Turkey (Türkiye)