Trials / Active Not Recruiting
Active Not RecruitingNCT07327996
Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial
Evaluation of Post-operative Pain and Bacterial Load Reduction After Incorporation of Mesoporous Silica Nanoparticles in Calcium Hydroxide Intracanal Medicament in Mandibular First Molar Teeth With Necrotic Pulp. "Randomized Controlled Clinical Trial"
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- Sponsor
- Future University in Egypt · Academic / Other
- Sex
- All
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp. It tests whether adding mesoporous silica nanoparticles-antibacterial particles-to calcium hydroxide makes the treatment more effective. Forty-two adult patients will be randomly assigned to receive either calcium hydroxide alone, nanoparticles alone, or a mix of both for one week during root canal therapy. measure patients' pain levels after 6h,12h,24,48h and 72 hours from treatment and the number of bacteria before and after treatment to see which method gives the best results. The goal is to make root canal treatments more comfortable and successful for future patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Calcium Hydroxide Intracanal medication | root canals filled with calcium hydroxide paste as intracanal medication for 1week |
| PROCEDURE | mesoporous silica nanoparticles paste | root canals filled with mesoporous silica nanoparticles for 1 week |
| PROCEDURE | Calcium Hydroxide + mesoporous silica nanoparticles | Root canal filled with Intracanal medication by combination between mesoporous silica nanoparticles with calcium hydroxide paste for one week. |
Timeline
- Start date
- 2025-09-01
- Primary completion
- 2026-04-30
- Completion
- 2026-07-01
- First posted
- 2026-01-08
- Last updated
- 2026-01-08
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT07327996. Inclusion in this directory is not an endorsement.