NCT07327268

Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS

Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS Patients With Mechanical Ventilation

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Although the theoretical model of "cyclic on-off switching of pulmonary blood flow" provides a crucial perspective for understanding VILI, its clinical validation and real-time intervention face significant obstacles. The fundamental reason lies in the lack of pulmonary microcirculation monitoring technology capable of bedside, non-invasive, continuous operation with sufficient spatiotemporal resolution. Nowadays, a novel 3D-EIT can perform real-time and non-invasive assessment of the distribution of pulmonary blood flow. However, if 3D-EIT can help to identify "cyclic on-off switching of pulmonary blood flow" is still unclear.

Conditions

• ARDS (Acute Respiratory Distress Syndrome)
• Electrical Impedance Tomography (EIT)
• Pulmonary Perfusion

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2026-01-08
• Last updated: 2026-01-08

Locations

1 site across 1 country: China