NCT07326436

Comparison of Sympathetic Blockade Duration in Brachial Plexus Blocks Performed by Different Methods

Comparison of Sympathetic Block Duration and Rebound Sympathetic Activity Rate in Infraclavicular and Supraclavicular Brachial Plexus Blocks Using Perfusion Index and Skin Temperature

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Bozyaka Training and Research Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This prospective comparative study will evaluate the sympathetic effects of ultrasound-guided infraclavicular versus supraclavicular brachial plexus blocks in adults undergoing upper-extremity surgery. Sympathetic tone will be monitored noninvasively with simultaneous bilateral measurements of perfusion index (pulse-oximetry-derived) and skin temperature obtained at baseline and at predefined post-block intervals until return to baseline. The primary outcome is the duration of sympathetic block. Secondary outcomes are between-approach differences in the time course of perfusion index and skin temperature, and the incidence and magnitude of rebound sympathetic activity.

Conditions

• Anesthesia, Conduction
• Brachial Plexus Blockade
• Sympathetic Blockade

Interventions

Type	Name	Description
PROCEDURE	Supraclavicular brachial plexus block	A linear US probe (7-13 MHz) will be placed in the supraclavicular area in the coronal oblique plane, in-plane technique will be used, and after antisepsis of the area to be blocked, injection will be performed from lateral to medial direction using a 22G 50 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan). Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.
PROCEDURE	Infraclavicular brachial plexus block	A linear US probe (7-13 MHz) will be placed in the infraclavicular area through a lateral sagittal approach, in plane technique will be used and injection will be performed using a 22G 100 mm stimulator needle (Stimuplex A®: B. Braun Melsungen AG, Japan) after antisepsis of the area to be blocked. Intermittent negative aspiration will be performed during all procedures to detect possible vascular puncture. A total of 30 mL of 2% prilocaine containing 0.5% bupivacaine and 5 mcg/mL adrenaline in a 1:1 ratio will be used as local anesthetic.

Timeline

• Start date: 2023-03-01
• Primary completion: 2023-09-01
• Completion: 2023-09-02
• First posted: 2026-01-08
• Last updated: 2026-01-08

Locations

1 site across 1 country: Turkey (Türkiye)