NCT07323043

Comparison of Cough Response Between Tegilidine and Sufentanil as Pre-induction Agents in General Anesthesia

The Affiliated Lianyungang Hospital of Xuzhou Medical University

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 190 (estimated)
• Sponsor: The First People's Hospital of Lianyungang · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled, double-blind study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or tegilidine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds.

Detailed description

Using a computer-generated randomized number table, patients were divided into two groups: the experimental group receiving Tiliglitidine (T group) at 20-50ug/kg, and the control group receiving Sufentanil (S group) at 0.4 μg/kg. After patients arrived in the operating room, routine monitoring including non-invasive blood pressure, electrocardiogram, and oxygen saturation was performed, and intravenous access was established. Patients were oxygenated and given the study drug before anesthesia induction. No other drugs were administered to the patients before giving the study drug. During anesthesia induction, patients received intravenous injection of Tiliglitide or Sufentanil according to their group. The severity of coughing was graded based on the number of coughing episodes: graded by the number and duration of coughs: Grade I, no cough, breathing regular; Grade II, a single mild cough; Grade III, multiple coughs, lasting less than 15 seconds; Grade IV, continuous coughs, lasting more than 15 seconds.

Conditions

• General Anesthetic Drug Adverse Reaction

Interventions

Type	Name	Description
DRUG	Tegilidine	Inject Tegilidine in the induction of general anesthesia
DRUG	Sufentanil	Inject Sufentanil in the induction of general anesthesia

Timeline

• Start date: 2026-01-15
• Primary completion: 2026-05-16
• Completion: 2026-06-16
• First posted: 2026-01-07
• Last updated: 2026-02-04

Locations

1 site across 1 country: China