NCT07322744

Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients

Association Between Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium According to Frailty Status in Older Surgical Patients: A Prospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 6,475 (actual)
• Sponsor: Chinese PLA General Hospital · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear. This study aimed to evaluate the frailty-stratified association between preoperative LMR and POD in older surgical patients.

Conditions

• Postoperative Delirium (POD)
• Frailty at Older Adults
• Lymphocyte

Timeline

• Start date: 2020-04-01
• Primary completion: 2022-04-30
• Completion: 2023-12-30
• First posted: 2026-01-07
• Last updated: 2026-01-09

Locations

1 site across 1 country: China