NCT07320755

Analysis of Computed Tomography Derived Maps for Determining Changes of the Liver Volume After Exposure to Radiotherapy

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 70 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Radiotherapy is commonly used to treat cancers involving the liver or nearby organs. While effective, radiation exposure can affect healthy liver tissue and may lead to changes in liver size and function. Monitoring these changes is important to improve treatment planning and reduce the risk of liver-related complications. This study aims to evaluate changes in liver volume using computed tomography (CT) imaging before and after radiotherapy. By analyzing CT-derived liver maps, the study seeks to better understand how the liver responds to radiation treatment over time. The study will include patients who undergo radiotherapy and have CT imaging performed as part of their routine clinical care. No additional procedures or treatments will be required for participation. The findings of this study may help improve future radiotherapy planning and patient monitoring by providing better information on liver volume changes following radiation exposure.

Detailed description

Radiotherapy plays a central role in the management of primary and metastatic tumors involving the liver or adjacent anatomical regions. Despite advances in radiation delivery techniques, the liver remains a radiosensitive organ, and radiation-induced liver injury continues to be a clinically significant concern. Quantitative assessment of liver volume changes may provide valuable insight into hepatic response and tolerance to radiation exposure. This study is designed to analyze computed tomography (CT)-derived liver volume maps to assess changes in liver volume following radiotherapy. CT images acquired as part of standard clinical practice will be used to generate volumetric measurements of the liver at baseline and during post-treatment follow-up. Advanced image analysis techniques will be applied to evaluate spatial and global liver volume changes. The study is observational in nature and does not involve any investigational drugs or devices. All imaging data will be obtained from routine clinical workflows without modification to standard patient care. Demographic, clinical, and treatment-related parameters may be correlated with observed liver volume changes to explore potential associations. The results of this study are expected to enhance understanding of radiation-related hepatic effects and support optimization of radiotherapy planning strategies. Improved knowledge of liver volume dynamics may contribute to better prediction of treatment-related toxicity and support individualized patient management in future clinical practice.

Conditions

• Intra-abdominal Malignancies
• Liver as Organ at Risk
• Radiation-related Liver Changes

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-01-01
• Completion: 2027-12-31
• First posted: 2026-01-06
• Last updated: 2026-01-09