NCT07320677

Finding Heart Failure in Those Prescribed Loop Diuretics in Primary Care in Jersey

Finding Heart Failure in Those Prescribed Loop Diuretics in Primary Care in Jersey (FIND-HF LOOP)

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Government of Jersey · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn whether a simple blood test screening pathway can help diagnose heart failure earlier in adults in primary care who take loop diuretic medicines (such as furosemide or bumetanide) but do not have a recorded diagnosis of heart failure. The main questions it aims to answer are: 1. Does offering a NT-proBNP blood test to eligible patients increase the number of new heart failure diagnoses within 12 months compared with usual care? 2. Does this screening pathway also uncover other important heart problems, such as irregular heart rhythms (arrhythmias) or valve disease? This is a cluster randomised controlled trial, which means that whole GP practices, rather than individual patients, are randomly assigned to one of two approaches: 1. NT-proBNP screening pathway, in which eligible patients are invited for a NT-proBNP blood test 2. Usual care, in which patients continue to be managed as they normally would without proactive screening Participants will: Be identified from GP records if they are prescribed loop diuretics and have no prior diagnosis of heart failure In screening practices, be invited to attend for a free finger-prick NT-proBNP blood test and brief questionnaire Be referred to the heart failure team and invited for an echocardiogram (a heart ultrasound scan) and further assessment if their NT-proBNP level is higher than 125 pg/mL Researchers will compare outcomes between screening and usual-care practices after 12 months, focusing on new diagnoses of heart failure. They will also look at other important cardiovascular findings, such as new arrhythmias, valve disease, and heart failure hospitalisation rates.

Conditions

• Heart Failure
• Diuretics

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	NT-proBNP screening	Patients in the intervention arm will be invited for a free point of care NT-proBNP blood test

Timeline

• Start date: 2025-11-01
• Primary completion: 2027-03-01
• Completion: 2027-07-01
• First posted: 2026-01-06
• Last updated: 2026-01-06

Locations

1 site across 1 country: Jersey